α Globin Hemoglobinopathy as A Case Study: Mutants and Prototype Mutants: Are They Absent α0, Reduced α+ or Recombinant?
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چکیده
منابع مشابه
Multiple mutants of a psychrophilic α-amylase 1 Stepwise adaptations to low temperature as revealed by multiple mutants of a psychrophilic α-amylase from an Antarctic bacterium*
Background: Cold-adapted enzymes remain catalytically active at low temperatures. Results: Mutants of a cold-adapted alpha-amylase stabilized by engineered weak interactions and a disulfide bond have lost the kinetic optimization to low temperatures. Conclusion: The disappearance of stabilizing interactions in psychrophilic enzymes increases the dynamics of active site residues at low temperatu...
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ژورنال
عنوان ژورنال: Cellular & Molecular Medicine: Open access
سال: 2017
ISSN: 2573-5365
DOI: 10.21767/2573-5365.100033